Assuntos
Coma/induzido quimicamente , Ifosfamida/efeitos adversos , Imunossupressores/efeitos adversos , Psicoses Induzidas por Substâncias/etiologia , Adulto , Coma/diagnóstico , Coma/terapia , Feminino , Humanos , Síndromes Neurotóxicas/diagnóstico , Síndromes Neurotóxicas/etiologia , Síndromes Neurotóxicas/terapia , Psicoses Induzidas por Substâncias/diagnóstico , Psicoses Induzidas por Substâncias/terapiaRESUMO
No disponible
Assuntos
Feminino , Adulto , Humanos , Ifosfamida/efeitos adversos , Síndromes Neurotóxicas/diagnóstico , Psicoses Induzidas por Substâncias , Coma , Neoplasias do Colo do Útero/tratamento farmacológicoRESUMO
The usefulness of external and interstitial radiotherapy in the treatment of prostatic carcinoma is well-documented. We report on our experience in 23 cases using interstitial Au-198 seed implants in combination with external radiation. The diagnostic protocol and therapeutic approach are described. Local control was achieved in 73% and the disease-free survival at 36 months was 49%. The mean follow-up was 44 months. The problems resulting from TUR and the different factors that might be responsible for the failure of local treatment are discussed.
Assuntos
Carcinoma/radioterapia , Neoplasias da Próstata/radioterapia , Idoso , Idoso de 80 Anos ou mais , Braquiterapia , Seguimentos , Radioisótopos de Ouro/administração & dosagem , Radioisótopos de Ouro/uso terapêutico , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Sixty-one patients, who refused surgery or whose overall medical status advised against radical cystectomy, were submitted to radical radiotherapy at the Oncology Radiotherapy Service of the General Hospital of Asturias. Irradiation was performed in a cobalt therapy unit. Radiation dose ranged from 50-70 Gy, with a daily dose of 190-200 cGy. Local control was achieved in 71% for stage A, 68% for B1. 17% for B2, and 0% for stage C. Disease-free survival was 63% for stage A, 48% for B1, 14% for B2, 0% for C, and 17% for D1. Overall disease-free survival was 20%, and the morbidity and mortality rates were 11.4% and 3.2%, respectively. In view of the poor results achieved in our setting, we have considered using combined external and interstitial radiation for tumors localized in the muscle layer, and adjuvant chemotherapy for stage C tumors (or those infiltrating perivesical fat).
